PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

  PRINCIPLE OF ANTI-MICROBIAL THERAPY Selection of Anti-microbial therapy  1)organism‟s identity  2)organism‟s susceptibility to particular agent 3)site of infection  4)patient‟s factor  5)safety of agent  6) cost of therapy

ARENERGIC BLOCKER/SYMPATHOLYTICS Bind to adrenoreceptors reversibly or irreversibly, preventing its activation by endogenous catecholamine.   CLASSIFICATION α Blockers Phenoxybenzamine , Phentolamine, Prazocin, Terazocin, Doxazocin, Yohimbine, Alfuzosin, Tamsulosin β Blockers  Propranolol, Metoprolol, Acebutolol, Atenolol, Betaxolol, Bisoprolol, Carteolol, Carvedilol, Esmolol, Labetalol, Nadolol, Nebivolol, Penbutolol, Pindolol, Timolol Inhibiting reuptake or release Guanethidine, Reserpine Phenoxybenzamine: non-selective, α1 & α2 blocker, irreversible, non-competitive, MOA:  covalently block the α1 & α2 adrenoreceptor..action last about 24hrs..body has to synthesize new receptor to overcome this block.. Actions:  vasodilation..decreased peripheral resistance provoke Reflex Tachycardia… Not used in Hypertension b/c its blockade release more nor-epinephrine which stimulate β receptor…. Epinephrine Reversal b/c by blocking α adrenoreceptor it bloc...

Sympathomimetics/Adrenergic agonists These drug act on adrenergic receptors by activating it ..    

Cholinergic anatagonist/ cholinergic blocker/Parasympathetolytic/Anticholinergic  /Antimuscarinic   These agents selectively block muscarinic receptors of parasympathomimetic nerves  Atropine= tertiary amine…Belladona alkaloid…Hyocyamine active isomer MOA: bind competitively prevent Ach from binding to those receptor act both centrally and peripherally Effects   Produce Cycloplegia; inability to focus near vision….unresponsive to light Mydriasis : dilation of pupil by contracting radial muscle & dilating ciliary muscle  Antispadmodic: reduce activity of GIT  Tachycardia, reduce the hypermotility of urinary bladder, secretions increase temp.of  body can be dangerous in childern and elderly  T.E: measurement of Refractive error  Antispasmodic antidote for cholinergic agonist  Antisecretery healing of peptic ulcer S.E blurred vision, sandy eyes, Dilirium, hallucination..  Classification:  Antimuscarinic agents Atropine, Benzt...