PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

 STEROID HORMONE & ANTAGONIST Removal of Hormone OR Treatment with Hormone to regress Tumor Orcheictomy =removal of both testes in Prosthatic cancer Prednisone Synthhetic, Anti-inflammatory Corticosteroid…Cortisol at high dose,Lymphocytolytic, ↑uric acid due to breakdown of Lymphocytes MOA inactive…reduced to Prednisolone by 11-β-hydroxysteroid dehydrogenase… Bind to receptor & trigger production of Specific proteins S.E ulcer, Pancreatitis, Hyperglycemia, Glaucoma, Osteoporosis, Tamoxifen  Estrogen antagonist…used in Estrogen-Positive Breast cancer… SERM (Selective Estrogen Receptor Modulator) weak Estrogenic activity Toremifene  used in Breast cancer in Postmenupausal women MOA Bind to Estrogen receptor.complex is nonfunctional…↓Estrogen…used with GnRH analog Leuprolide ↓Estrogen level S.E Thromboembolism,Vision blurred, Hypercalcemia, Vaginal bleeding,Hot flash Aromatase inhibitors Aromatase reaction=↑Estrogen synthesis from Androstenedione in liver,fa...

ANTIBIOTICS Cell non-specific Dactinomycin  called Actinomycin D…used with Vincristine in Wilms tumor…with MTX in Soft tissue carcinoma MOA= form stable Dactinomycin-DNA compex b/w base pair of DN …interfere with DNA-depenndent RNA polymerase… single stand break by free radical or by action on Topoisomerase ll S.E =Extravasation, Stomatitis, Doxorubicin & Daunorubicin  Anthracycline antibiotics…Idarubicin, Epirubicin are analogof Daunorubicin… MOA =Doxorubicin induced free radical…memb. Lipid peroxidation…DNA strand scission…Direct oxidation of Purine, Pyrimidine, Thiol, Amine S.E= Cardiotoxicity…Dark red color vein….Dexrazone (iron chelator) used to prevent cardiotoxicity….↑skin pigmentation Bleomycin G2 Phase specific…mix of Cu-chelating Glycopeptide…. MOA= DNA-Bleomycin Fe2+ undergo into Oxidation Bleomycin-Fe3+…Superoxide form attack on Phosphodiester bond…Scission of DNA strand S.E= Pulmonary toxicity “Bleomycin lung”. ALKYLATING AGENTS Alkylating agent covalent...