PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

Diabetes Mellitus Heterogenous group of syndromes characterizes by elevated Blood Glucose level caused by relative or absolute deficiency of INSULIN. Pancreas is an Endogenous gland, produces Insulin, Glucagon, Somatastatin… Pancreas is also an exogenous gland produce digestive enzymes…β-cells produce insulin, α-cells Glucagon, δ-cells produce Somatostatin… Click and learn insulin conceptually Type-1 Diabetes Mellitus  young individual, Autoimmune destruction of β-cells, Pancreas fail to respond Glucose……..required Exogenous Insulin to avoid Catabolic state characterized by Hyperglycemia & Ketoacidosis….. Insulin deficiency symptoms Polydipsia, Polyphagia, Polyuria, weight loss Type-2 Diabetes Mellitus  by Genetic factor, obesity, aging, peripheral insulin resistance older patients...β-cells become resistance to insulin...infection lead to Amputation Gestational Diabetes Mellitus  abnormality ofglucose in first term of Pregnancy Insulin & its analogue MOA insu...

 Adrenocorticotropin Hormone ACTH (Coticopropin) Require for melanin production…used in west syndrome…target organ Adrenal cortex.. Side effects= osteoporosis, peripheral edema, hypokalemia Somatotropin (Growth Hormone) In Anterior pituitary… Secretion of this hormone inhbited by Somatostatin… Acromegaly increase growth due to high GH ... used in Prader-Wili Syndome, AIDS west syndrome,short bowel syndrome…used in Paeds with Closed Epiphyses Antiaging hormone = called antiaging hormone bcz it increase Lean body mass, bone density, skin thickness, adipose tissue mass decreases…..abuse by some Athletes half life of GH 25min , produce IGF-I(Somatomedin C) produce action like GH S.E= Pt. develop Diabetes, avoid in pt. with inresed intracranial pressure, Diabetes Retinopathy, Obese pt. with prader-willi syndrome Somatostatin (Growth hormone –inhbiting hormone) Bind to SSTR2 & SSTR5….suppresGH & Thyroid stimulating hormone…found in intestine & pancreas…obtain from Hyp...