PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

  Pain =unpleasant sensation acute or chronic consequence of neurochemical processin the peripheral and CNS. Opioids are natural or synthetic compounds that prodce Morphine-like effect Opioids Receptors= Protein receptors in CNS ,periphery and GIT..μ(mu), k(kappa), δ(delta) .. Morphine= Prototype, high affinity for μ receptor MOA= inhibit Adenylyl cyclase..increase K+ ion ..hyperpolarization..decrease Ca++influx ..Morphine act at k receptor in spinal cord & decrease Substance P..modulate pain ACTIONS= Analgesic by rising pain threshold in spinal cord & altering pain perception in brain...Euphoria..Respiratory Depression..Depression of Cough reflexes..Miosis(pin point pupil)....Emesis by stimulating CTZ..decrease GIT movement..Dilate CSF so contra in Brain injury..Histamine release..increase Growth hormone.. Prolong Labor T.E= induce Sleep...treatment of Diarrhea...Relief of Cough...treatment of Acute Pulmonary Edema P.K= linear P.K..First pass met..Morphine-6-Glucuronide p...

  Anxiety: unpleasant state of tension, apprehension, uneasiness, Classification  Benzodiazepens Bezodiazepene=composed of α , β , γ..BZD binds to GABA receptor at specific site located at the interface of α & γ2 subunit...influx of Cl- ions...hyperpolarization... Θ action potential Two BZD receptors BZ1 & BZ2 Actions  reduction of anxiety....sedation...Anticonvulsant....Muscle relaxant. .Anterograde Amnesia.. T.E  used in GAD(Generalized Anxiety Disorder),  PTSD (Post Traumatic Stress Disorder),  OCD(Obsessive Compulsive Disorder),  Phobia, Social Anxiety,  for Panic disorder Alprazolam is effective In Muscular Disorder Diazepam used.  Midazolam induce Anaesthesia Diazepam & Lorazepam DOC in Grand-Mal Epileptic disorder.. Clonazepam in Seizure Flurazepam (85hr t1/2) , Temazepam used in REM(Rapid Eye Movement) Triazolam used in induction of sleep S.E  drowsiness & confusion, Ataxia, weight gain, sexual dysfunction Contrai...