CNS STIMULANT - BASIC NEUROPHARMACOLOGY
Methylxanthines Theophylline, Caffeine, Cocaine... MOA Inhibit PhosphodiEsterase enzymes..Increase cAMP ....Block Adenosine receptor...Alter intracellular Ca++..Increase Ca++ in Brain..decrease Ca++ in smooth muscles Actions increased mental alertness. +Ve ionotropic & chronotropic effect on heart.. .. Diuretic action...Stimulate secretions... contraindicated in Peptic ulcer.. T.E in Asthma.... in Headache... S.E Insomnia.... cardiac arrhythmia... Nicotine second most abused drug. MOA cause ganglionic stimulation by depolarization..At high dose blockade of ganglia Actions Euphoria...arousal...respiratory paralysis...Vasoconstriction.... increaase B.P....Appetite suppressant S.E Diarrhea, tachycardia, withdrawal characterized by irritability, anxiety, difficulty in conc. Headache, insomnia... Bupropion used to reduce craving for smoking Varencilline Partial agonist at neural nicotinic Ach receptor in CNS...used ...