COLLIGATIVE PROPERTIES - PHARMACEUTICAL PRINCIPLES AND DRUG DOSAGE FORMS
Colligative properties of solutions are properties that depend upon the concentration of solute molecules or ions, but not upon the identity of the solute. Colligative properties include vapor pressure lowering, boiling point elevation, freezing point depression, and osmotic pressure. Lowering the Vapor Pressure: Let's first remind ourselves about what vapor pressure is and what affects it chemically and physically. In a closed container, a liquid will evaporate until an equal amount of molecules are returning to the liquid state as there are escaping into the gas phase. The pressure of the vapor phase above the liquid at this point is called the equilibrium vapor pressure. This vapor pressure is dependent on a number of factors, including the temperature of the system (kinetic energy is required to help the molecules escape into the gas phase), the pressure of the system (high pressure can keep the gas contained in the liquid e.g. a bottle of coke), and also the intermolecular f...