PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

 PROSTAGLANDIN Unsaturated Fatty acids containing 20 carbon, also called “Eicosanoid” Synthesis= Arachidonic acid “20 carbon fatty acid” precursor of PG(Prostaglandin) ... Free Arachidonic acid release from Phospholipid by action of Phospholipase A2 Cyclo-Oxygenase Pathway= PG synthesized through Cyclooxygenase pathway... Cyclooxygenase 1= responsible for Physiologic production of PG ...  Involved in Platelet Aggregation, Gastric Cytoprotection, Homeostasis, Reproduction, Kidney function Cyclooxygenase 2= ↑PG level in Chronic disease & Inflammation...Expressed in Brain, Bone, Kidney....Θ by Glucocorticoid Lipoxygenase Pathway= Lipoxygenase Act on Arachidnic acid to form 5-HPETE, 12-HPETE, 15-HPETE (HydroPeroxyEicosa TetraEnoic Acid)...Leukotriene & Lipoxin produced involved in Asthma Actions of PG= via Gprotein which Activate or Inhibit Adenylyl cyclase...Stimulate Phospholipase C...Activate Sec-Messenger DAG & Inositol Triphosphate PGF2α, TXA2, LeuT involved in P...