ADRENAL HORMONES - SYNTHESIS FUCNTION AND IMBALANCE OF ADRENAL HORMONE | PHARMACOLOGY REVIEW
Adrenal gland consist of cortex & medulla.... Medulla secrete Epinephrine... Cortex secrete Adrenal Corticoids & Adrenal Androgens
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THE AUTONOMIC NERVOUS SYSTEM
Nervous system divided in 1)CNS 2)PNS Peripheral Nervous sys . PNS: 1)Efferant division (brain to peripheral) 2)Afferant division(peripheral to brain) Efferant Division: Motor neurons 1)ANS Autonomic Nervous Sys. 2)Somatic sys. ANS divided in 1)ENS (Enteric nervous sys) 2)PNS ( parasympathic nervous sys) 3)SNS (sympathic nervous sys). ANS : Involuntary/Visceral/Vegetative=regulates the everyday requirement of vital bodily function without conscious participation of mind Somatic SYS .: Voluntary control of functions such as contraction of skeletal muscle Sympathic Neurons: 👉Preganglionic neurons of sympathetic come from T1-L2 of spinal cord-------short compare to postganglionic neurons Response to stressful situation such as trauma,cold,hypoglycemia,exercise Fight or Flight response ---release of adrenaline(epinephrine) & lesser amount of norepinephrinee. Parasympathetic system: maintain the...
Pharmacokinetic (Absorption, distribution, metabolism and elimination)
must read the bold points what happens when you eat a pill ? Pharmacokinetics : describe drug absorption, distribution, metbolism and elimination Routes of drug administration: 1) Omeprazole are acid unstable, enteric-coated preparation. 2) Aspirin have irritating effects on stomach, enteric-coated preparation 3) t1/2 of Morphine is 2-4 hours, oral morphine need 6 times in 24hrs, need extended release preparation 4) nitroglycerein is sublingual 5) Atracurium, neuromuscular blocker, i/v administered, not absorbed orally 6) I/V bolus: full amount of a drug is delivered to the systemic circulation almost immediately 7) I/V infusion: full amount of drug administered slowly during a long time 8) Depot preparation: suspension of drug in a non-aqueous vehicle such as polyethylene glycol e.g Erythromycin, haloperidol(anti-psychotic/neuroleptic),medroxyprogesterone(contraceptive) 9) sub-cutaneous: Epinephrine ,Lidocaine , ins...