PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

 1g Tumor mass=109 cells smallest tumor burden …clinical symptoms appear at this stage Palliative Chemotherapy = survival is extended Curative Chemotherapy(Adjuvant)= Solid tumor (i.e Testicular carcinoma)…Reduced by surgery or Radiation… 🌟Treatment of Micrometastasis continue after cancer disappear Curative chemotherapy(Non-adjuvant)= Dissaminated cancer(i.e Leukemia…Drug-chemotherapy to reduce tumor before surgery…  Each drug have different Organ toxicity& Site of action  Log kill=Destruction of cancer cell by Anticancer follow 1ST Order kinetics…5-log kill 105 cells  POMP=For Acute Lymphocytic leukemia;  Prednisone, Oncovin, Methotrexate, Purinethol. Used for 21days ANTI-METABOLITES “S” phase….Cell-Cycle Specific Methotrexate=Structure related to Folic Acid….Inhibit DHFR (Dihydrofolate reductase) MOA= enter into the cell by active-transport system same like N5-methylFH4…ϴ Folate→FH2 by DHFR…ϴFH2→FH4 by DHFR…inhibit formation ofN5,N10-Methylene-FH4 C...

  Right answers of Anti microbial MCQs  Right answer : A  Because of structural similarity with pyridoxine . Isoniazid increases the excretion or pyridoxine, which can lead to peripheral neuritis, particularly in poorly nourished patients. Pyridoxine (a form of vitamin B6) deficiency may cause convulsions as well as the neuritis, involving synovial tenderness and swelling. Treatment with the vitamin can reverse the neuritis and prevent or cure the seizures. Right answer: B Right answer : E Right answer : E Right answer : D

 Nucleoside Reverse Transcriptase Inhibitor NRTI Zidovudine approved in 1987 used to Suppress Replication of HIV & Restore no.of CD4+ cells in AIDS patients HAART=”Highly Active Antiretroviral Therapy” include NRTI, NNRTI, Protease Inhibitor, Entry Inhbitor, Integrase Inhbitor e.g 2NRTIs + 1Prot.Inhibitor OR 1NNRTI+1Integrase inhibitor MOA:  👉NRTI are RiboNucleoside analogue…lack 3-OH...Enter the cell convert into TriPhosphate…incorporate into Viral DNA by Reverse transcriptase…. b/c 3-OH not present, 3,5-Phosphodiester bond not fromed in Nucleoside Triphosphate...T erminate Elongation of DNA 1. HIV enters into cell→Maraviroc (Entery Inhibitor) block entery of HIV 2. Enfuvirtide (Entery In.) block FUSION of HIV & Host memb Viral RNA→═Viral DNA by Reverse Transcriptase, NRTI & NNRTI ϴ this enzyme ═Viral DNA integrate with ═Host DNA Integrase Inhibitor ϴ this process ≈Integrated Viral DNA convert into Viral RNA & Precursor Polyprotein, Precursor Protein→Viral...