PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

Infectious diseases caused by fungi called Mycosis ….cell wall composed of chitin…Contain Ergosterol Cutaneous Mycosis/Epidermis = Superficial infection invoving skin … Drugs for Subcutaneous & Systemic inections Amphotericin B (Fungicidal/Fungistatic) From S.nodosus DOC in Systemic mycosis… MOA bind to Ergosterol...form pore… Allowing leak of Electrolytes & small molecules…cell death Antifungal spectrum   activity against Candida albican, Histoplasma capsulatum,Cryptococcus neoforamans, Coccidicoides immitis, Blastomyces dermatitidis, Apergillus P.K  insoluble in water, Deoxycholate added to form colloidal suspension ↓Nephrotoxicity. …  Liposome formulation AMBISOME, AMPHOTECT, ABELCET… S.E  fever & chills, Thrombophlebitis, Nephrotoxicity, Hypotension, normocytic anemia exacerbate in HIV pt receiving Zidovudine Flucytosine (Fungistatic) Pyrimidine metabolite. MOA 5-FC enter via Cytosine permease… 5-FC converted 5-Flourodeoxyuridine 5-monophosphate (...

  Quinolone   Learn with  fun     by clicking the fun Naldixic acid is precursor of Flouroquinolone MOA enter into bacterium by Passive Diffusion through Porin ϴ replication of bacterial DNA by interfering Topoisomerase ll & Topoisomerase IV during bacterial Growth & Reproduction… Topoisomerase ll(DNA Gyrase) change DNA topology by nicking, pass through , resealing mechanism…..ϴ of Topoisomerase ll inhibit resealing step….cell death by cleavage of DNA  Topoisomerase lV required for cell division. Antibacterial spectrum 1st Generation in treatment of UTI, have moderate Gram-Ve rod activity. 2 nd Generation Expanded Gram-Ve activity rod, some Gram+Ve cocci activity &  against atypical organisms (M.pneumoniae, Chlamydia pneumonia)   3 rd Generation improved activity against Gram-Ve rod, Gram+Ve cocci, atypical organism 4th Generation activity against Gram+Ve cocci, Gram+Ve rod, Gram-Ve rods, Anaerobes T.E 👉Ciprofloxacin is DOC in A...

Bacterial ribosome 70s (50s+30s) Mammalian ribosome 80s (60s+40s) Tetracyclines (Bacteriostatic /Bacteriocidal)  Group of fused 4 rings  MOA enter into susceptible organisms by Passive diffusion & by an energy dependent mechanism to cell memb bind reversibly to 3OS subunit of ribosome  blocking access of acyl-tRNA into mRNA ϴ protein synthesis Anti-bacterial synthesis= Gram +Ve Bacilli ( Bacillus anthracis), Gram –Ve  Rod(Brucella, Vibrio, Yersinia pestis) anaerobe,Spirochete, Mycoplasma, Chlamydia  Resistance: due to alteration in R factor, Mg dependent efflux, TetA protein,  T.E:  Doxycycline used in Cholera (Vibrio cholera), Lyme disease (Borrelia burgdoferi), Chlamydial infection (Chlamydia trachomatis, Chlamydia psittaci), Mycoplasma pneumonia, Tetracycline in Rocky Mountain spotted fever (Ricketssia rickettsii), P.K   form non-absorbable chelate with Ca in dairy products … bind to tissue undergo Calcification   (teeth, bone, Gastric...

 Anti – microbial drug selectively interfere with synthesis of bacterial cell wall  Pencillins MOA:  interfere with last step of Bacterial cell wall synthesis (Transpeptidation/Cross-linkage)….result in exposure of Alteration in Osmotically memb…Cell lysis occur … either though Osmotic pressure or by Autolysin….Pencillin effective only against rapid growing bacteria  Pencillin-binding Protein  1. PBP are bacterial enzymes involved in synthesis of cell wall   2. PBP involved in maintenance of morphological feature… Pencillin also cause changes in morphological feature  Inhibition of Transpeptidase PBP catalyze cross-linkage b/w Peptidoglycan chain….  Pencillin inhibit this Transpeptidase-Catalyzed reaction…. the cross-linkage formation essential for integrity of cell wall…. As a result” Park Nucleotide” UDP-acetylmuramyl-Ala-D-Gin-L-lys-D-Ala-D-Ala accumulation  Production of Autolysin  Gram+Ve cocci produce degradative enzyme “Auto...