PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

Drugs used to treat Erectile Dysfunction Erectile Dysfunction= inability to maintain Penile erection for successful performance of Sexual activity ED has physical & psychological causes including vascular disease, diabetes, medications, depression, prostatic surgery Classification Drugs for Erectile Dysfunction (PhosphoDiEstrase-5 inhibitor) Sildenafil Tadalafil Vardenafil Previous therapies include intrapenile inj of Alprostadil, penile implant Phosphodiestrase-5 inhibitor PDE-5 MOA NO activate Guanylyl cyclase... form cGMP... ↓ intracellular Ca++.....relaxation  of smooth muscles...PDE-5 responsible degradation of cGMP... PDE-5 inhibitors Θ  PDE-5.... Increase blood flow into Corpus Cavernosum at any level of sexual stimulation No effect in the absence of sexual stimulation P.K  should be taken 1hr prior to sexual activity... Erectile enhancement upto 4hr.. Abs.   delayed by high fat meal... Disintegrating tab of Vardenafil not affected by fat meal ... S.E ...

 OTHER PAST PAPERS OF AKUH Pharmacology   1) ______ is used to prevent H1N1 A)Amentadine B)Oselteamivir C)Acyclovire D)Ganciclovir  2) Competitive alters____ and non-competitive inhibitors alters______. A) Efficacy: Potency  B)Potency: Efficacy  C)Efficacy: efficacy  D) Potency: potency 3) ________ fungal infection is very difficult to irradiate. A) Nail B) Scalp C) Skin D) Mucous membrane            4) A 300 mg dose of a drug is given whose t1/2 is 6 months. What is the amount remaining after 2 years (F=1) (hint: exponential elimination) 5) ______ cream 1% is used in burn. A)cortisole B)clotrimazole C) Silver sulfadiazine D)        c is annnnns 6) _____ is used to treate scabies 7) A person allergic to easter type anesthetic, what would you give? A) Tetracain B) Bupivacain C) Procain D) All 8) Rauwolfia alkaloid is/are: A) Raserpine B) ephedrine C) bromocriptine D) All  9) Which prostaglandin is used i...

Classification Anti-Microbial Agents Optimal therapy for Patients with Peptic Ulcer disease who infected with Helicobacter Pylori.... Urea Breath Test: Exhaled 13CO2 analyzed...presence of H.Pylori increase ratio of 13CO2-12CO2 in Expired breath...H.pylori release UREASE hydrolyzes labeled Urea into 13CO2 Triple therapy consist of PPI, Metronidazole/Amoxicillin, Clarithromycin Quadruple therapy PPI, Metronidazole, Tetracycline, Bismuth subsalicylate GERD not associated with H.pylori H2-Receptor Antagonists Gastric acid secretion by parietal cells of mucosa stimulated by ; Histamine, Ach, Gastrin. Receptor binding results in activation of Protein Kinase....stimulate H+/K+- ATPase proton pump ...secrete H+ in exchange for K+ into lumen of Stomach.....Gastric acid production MOA= H2-receptor anatagonists block action of Histamine at all H2-receptor ... Competetively bind to H2-Receptor----- reduce intracellular conc. ATP....inhbit gastric acid secretion Potently inhibit 90% Basal, Food-...

RIGHT ASNWERS OF TRAINEE PHARMACIST TEST AKUH 2020   1. Solution 2.Diazepam 3.Unbound.  4.Which hypertensive cannot be given in gout? 5. B - blockers ( propranolol, acebutolol, atenolol) 6. Female mosquito. 7. Imipramine. BECAUSE IT IS TCA 8.Filgrastim used in Neutropenia. 9. Anticholinergic poisoning is treated with? (PHYSOSTIGMINE) 10. Morphine antidote? ( NALOXONE) 11. Benzodiazepine antidote? (FLUMAZENIL) 12. Organophosphate antidote? ( PRALIDOXIMINE & ATROPINE) 13. Anoxaperin antidote? ( PROTAMINE) 14. Para sympathetic system is also called Craniosacral sympathetic system is also called thoracolumbar 15. Vagal nerve is Cholinergic. 16.Detail information. 17.Which is not parenteral route of administration? Oral and chewable. 18 BBB is crossed by drug when Inflamed meningitis.  19. Creatinine clearance is determined through GFR. 20. Clearance and plasma drug concentration  21. Diuretics contraindicated in gout? Right answer : THIAZIDE 22. QRS com...