IMMUNOSUPPERESSANTS - THE PHARMACOLOGY OF IMMUNOSUPPRESENTS | PHARMACIST REVIEW

-

 
immunosuppressive drugs ppt immunosuppressants mechanism of action explain the process of immunosuppression pathophysiology of immunosuppression mechanism of immunosuppression immunosuppression effects on body systems immunosuppression pdf living with immunosuppression

Immune activation 3 signal model

Signal 1 =Antigen at APC(Antigen presenting Surface) react with T-Cell at CD3 receptor

Signal 2=CD80 & CD86 at APC engage with CD28 at T-Cell

Signal 1 & Signal 2 activate Calcium-Calcineurin Pathway, production of Cytokine i.e IL-2, IL-15, CD154, CD25.

Signal 3=IL-2 bind with CD25 at T-Cell activate mTOR (Mammalian Target of Rapamycin) , stimulate T-Cell proliferation



Selective Inhibitor of Cytokine

Immunosuppressant Drugs: A Complete Overview -

Cyclosporine=11 Amino acid polypeptide...

MOA= Bind to Cyclophilin(Immunophilin)...this complex bind to Calcineurin...ΘNFATc (Cytosolic Nuclear Factor of Activated T-Cell) dephosphorylation...block activation of NFATc...NFATc not enter the Nucleus & stimulate Production of IL-2...↓IL-2 ↓T-cell proliferation

T.E= prevent Rejection of Kidney, Liver, Cardiac transplant

S.E=Nephrotoxic, CMV infection, Gum Hyperplasia, Hirsutism (↑hairgrowth in women), ↑K+....Contra in Seizure

Tacrolimus=called FK506, Macrolide ...obtain from Fungus

MOA= same to cyclosporine but it Bind to FKBP-12(FK-binding protein) instead of

Cyclophilin

S.E=Nephrotoxicity, Neurotoxiciity, Hirsutism, Gingival hyperplasia, Diabetes

immunosuppressive drugs ppt immunosuppressants mechanism of action explain the process of immunosuppression pathophysiology of immunosuppression mechanism of immunosuppression immunosuppression effects on body systems immunosuppression pdf living with immunosuppression
Sirolimus=Sirolimus-stents into cardio due to Anti-Proliferative action

MOA=bind to FK-binding Protein...complex bind to Mtor...interfere with Signal 3.. Block

T-Cell proliferation from G1-S phase

S.E=Hyperlipidemia, Impair wound healing, Nephrotoxic....57-62hr half life

Everolimus=Sec-line agent in Renal cell carcinoma in 2009...Mechanism same to sirolimus

S.E=Hyperlipideia, Impair wound healing, Angioedema

IMMUNOSUPPERESSIVE ANTIMETABOLITES

Azathioprine : Prodrug...converted into 6-MP...then TIMP...Θde novo Purine synthesis

Mycophenolate Mofetil : Reversible, non-copmetitive blocker of IMP....ΘXPM(Xanthine

Monophosphate)...ΘGMP formation

S.E= Leukopenia, Anemia, CMV infection

immunosuppressants and covid immunosuppressant side effects immunosuppressants and coronavirus immunosuppressants mechanism of action staying healthy on immunosuppressants is levothyroxine an immunosuppressant working while on immunosuppressants immunosuppressant drugs for kidney transplant

ANTIBODIES

Polyclonal Antibody : effective against a no. of Lymphocyte antigen

Monoclonal Antibody : effective against specific antigen

Muro : antibody from Mouse

“Zu”:  Humanized antibody 90% Human, 10% Mouse

“Xi” : Chimerized antibody, 75% Human, 25% Mouse

Anti-Thymocytes Globilin : Thymocytes develop in Thymus, act as T-Cell precursor...

“Polyclonal antibody”...Act by Coplement-mediated destruction, Apoptosis, Opsonization Antibody-dependent cytotoxiciity

S.E=Lymphopenia, chill, fever, Thrombocytopenia

Muromonab : bind to CD3 receptor...block T-Cell synthesis...used in Renal carcinoma

IL-2 Receptor Antagonist= (Basiliximab & Daclizumab) Anti- CD25...Blocker of IL-2

Alemtuzumab : block CD52 receptor



Comments

Post a Comment

Popular posts from this blog

AGHA KHAN HOSPITAL PAST PAPER FOR PHARMACIST - IMPORTANT POINTS | SOLVED PAST PAPER

-
Image
RIGHT ASNWERS OF TRAINEE PHARMACIST TEST AKUH 2020   1. Solution 2.Diazepam 3.Unbound.  4.Which hypertensive cannot be given in gout? 5. B - blockers ( propranolol, acebutolol, atenolol) 6. Female mosquito. 7. Imipramine. BECAUSE IT IS TCA 8.Filgrastim used in Neutropenia. 9. Anticholinergic poisoning is treated with? (PHYSOSTIGMINE) 10. Morphine antidote? ( NALOXONE) 11. Benzodiazepine antidote? (FLUMAZENIL) 12. Organophosphate antidote? ( PRALIDOXIMINE & ATROPINE) 13. Anoxaperin antidote? ( PROTAMINE) 14. Para sympathetic system is also called Craniosacral sympathetic system is also called thoracolumbar 15. Vagal nerve is Cholinergic. 16.Detail information. 17.Which is not parenteral route of administration? Oral and chewable. 18 BBB is crossed by drug when Inflamed meningitis.  19. Creatinine clearance is determined through GFR. 20. Clearance and plasma drug concentration  21. Diuretics contraindicated in gout? Right answer : THIAZIDE 22. QRS com...
Read more

AKUH PAST PAPER | INTERVIEW AND SCREENING TEST QUESTIONS FOR TRAINEE PHARMACIST WITH REFERENCE AND ANSWER KEY

-
Image
 OTHER PAST PAPERS OF AKUH Pharmacology   1) ______ is used to prevent H1N1 A)Amentadine B)Oselteamivir C)Acyclovire D)Ganciclovir  2) Competitive alters____ and non-competitive inhibitors alters______. A) Efficacy: Potency  B)Potency: Efficacy  C)Efficacy: efficacy  D) Potency: potency 3) ________ fungal infection is very difficult to irradiate. A) Nail B) Scalp C) Skin D) Mucous membrane            4) A 300 mg dose of a drug is given whose t1/2 is 6 months. What is the amount remaining after 2 years (F=1) (hint: exponential elimination) 5) ______ cream 1% is used in burn. A)cortisole B)clotrimazole C) Silver sulfadiazine D)        c is annnnns 6) _____ is used to treate scabies 7) A person allergic to easter type anesthetic, what would you give? A) Tetracain B) Bupivacain C) Procain D) All 8) Rauwolfia alkaloid is/are: A) Raserpine B) ephedrine C) bromocriptine D) All  9) Which prostaglandin is used i...
Read more

COLLIGATIVE PROPERTIES - PHARMACEUTICAL PRINCIPLES AND DRUG DOSAGE FORMS

-
Image
  Colligative properties of solutions are properties that depend upon the concentration of solute molecules or ions, but not upon the identity of the solute. Colligative properties include vapor pressure lowering, boiling point elevation, freezing point depression, and osmotic pressure. Lowering the Vapor Pressure: Let's first remind ourselves about what vapor pressure is and what affects it chemically and physically. In a closed container, a liquid will evaporate until an equal amount of molecules are returning to the liquid state as there are escaping into the gas phase. The pressure of the vapor phase above the liquid at this point is called the equilibrium vapor pressure. This vapor pressure is dependent on a number of factors, including the temperature of the system (kinetic energy is required to help the molecules escape into the gas phase), the pressure of the system (high pressure can keep the gas contained in the liquid e.g. a bottle of coke), and also the intermolecular f...
Read more