PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

 Class l Na+ Channel Blocker  Block voltage gated Na+ channel like local anesthetics..slow the rate of rise of Phase 0.  High affinity for Active & Inactive channels..little effect on resting..decrease excitability & conduction velocity..  Cause Pro-Arrhthymic effects…… QT interval prolongation. Use- Dependance Class l bind to open or inactivated sodium channel than are fully repolarized…show great degree of blockade during depolarizing stage  Block the cell discharging at high frequency without interfering normal  mal one S.E=anticholinergic side effects like dry mouth, urinary retention,constipation etc Class lB = decrease Duration of Action Potential…rapidly interact with Na+ channel..little effect on Rate of Depolarization Lidocaine= Class lB drug...Local Anesthetic..Shorten Phase 3 repolarization.. T.E=used in Ventrical Arrhythmia in Myocardial Infarction(M.I)… S.E=Slurred speech, Paresthesia, Convulsion, Cradiac Arrhythmia Mexiletine ...

 HEART FAILURE HF=complex, progressive disorder in which the heart is unable to pump sufficient blood to meet the needs of the body. Symptoms ; Dyspnea, Fatigue, Fluid retention. Also called” Congestive Heart failure (C.H.F) Action Potential= Phase 0:Fast Upstroke: Na+ channels open (fast channel) resulting in afast inward current ……Sodium current is blocked by Quinidine Phase l: Repolarization: inactivation of Na+ channel…K+ channels rapidly open & close…outward current Phase ll: Plateau: Voltage sensitive Ca++ channels open…Slow inward current(depolarizing)…. Slow outward current (Polarizing) leak of K+ Phase lll: Repolarization Ca++ channels close…K+ channels open…outward current lead to repolarization… net gain of Na+ & Loss of K+….corrected by Na+/K+-ATPase Phase lV: Forward Current Increase depolarization from gradual increase in sodium….bring the cell to Threshold of next action potential. Angiotensin-Converting Enzyme Inhibitor Angiotensinogen (α2-globulin i...