PharmaPHILIA - Extracting Concepts Of Medical With Rph FIA

 Depression : intense feeling of sadness, hopelessness, despair symptoms that shows you are depressed SELECTIVE SEROTONIN REUPTAKE INHIBITORS MOA: inhibit serotonin reuptake...have little ability to block Dopamine Actions:  Citalopram & Fuloxetine are Racemic mixture..Escitalopram is S-enantiomer of Citalopram...Fuloxetine has 50hr t1/2. T.E:  treat Depression, Bulimia Nervosa, GAD, PTSD S.E: Sexual dysfunction, Suicidal ideation in Adults...Sleep disturbance.. Serotonin syndrome: Hyperthermia, muscle rigidity, Myoclonus muscle on withdrawl SEROTONIN/NOREPINEPHRINE REUPTAKE INHIBITOR Inhibit reuptake of both Serotonin & NorEpinephrine Venlafaxine & Desvenlafaxine= Desvenlafaxine is metabolite of Venlafaxine.. Duloxetine=Contraindicated in kidney impair.. T.E: used in Depression, Backache, MuscleAche, Diabetic peripheral neuropathy ATYPICAL ANTIDEPRESSENTS Mixed group of agents have action at different sites Bupropion : weak dopamine & norepinephrine reupt...

ALSO WATCH PRECISE VIDEOS OF ANTIMICROBIAL Parkinsonism Neurological disorder of muscle movement, characterized by Tremor, Muscular rigidity, Bradykinesia(slowness ininitiating & carrying voluntary  movement) , Postural and gait abnormalities. Etiology: imbalance b/w Substantia nigra & Neostriatum...Loss of DOPAMINE results in increased production of Ach in NEOSTRIATUM & decrease Inhibitory effect of DOPAMINE(produce in SUBSTANTIA NIGRA) on Ach... Levodopa  metabolic precursor of DOPAMINE...only provide Symptomatic relief MOA Dopamine does not cross B.B.B..Levodopa actively transported into CNS .converted into Dopamine in Brain... Carbidopa  DOPA decarboxylase inhibitor...Θ metabolism of Levodopa in GIT & Peripheral tissue...increasing availability of DOPA in brain T.E  2/3rd of Patient in Parkinson disase reduce severity of disease.. P.K levodopa 1-2 hr t1/2..ingestion of high protein(Amino ACIDS) may interfere in the transport of Levodopa...should b...