ANTIPSYCHOTIC DRUGS -Typical and Atypical Antipsychotic Drugs

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Called NEUROLEPTICS/MAJOR TANQUILIZER

Schizophrenia

delusion,hallucination, thinking or speech disturbance

First –Generation Antipsychotics/Conventional/typical/Traditional
Antipsychotics

Competitive inhibitor of various receptor....Block D2 receptor..

Second-Generation Antipsychotics/Atypical Antipsychotics

Have less Extra-Pyramidal effects than First-generation...more Efficacious..

MOA
block Dopamine receptor in the Brain..Block Serotonin receptor 5-HT in brain..
Refractory Patients= 20% patients do not responds First & Sec generation drugs.
.Clozapine effective but have side effect of Bone marrow suppression & CVS side effect
Actions
Antipsychotic actions; reduce hallucination & delusions with
Schizophrenia(+Vesymptoms)....
-Ve symptoms; Anhedolia (not getting pleasure from normal stimuli), Apathy, Impaired
attention
antipsychotic drugs classification pdf typical antipsychotics antipsychotics list antipsychotic definition atypical antipsychotics atypical antipsychotics side effects typical vs atypical antipsychotics antipsychotic drugs mechanism of action 1 2 Next



Extra-Pyramidal Effects
 Dystonia (Sustained contraction of muscles), Akathisia
(motor restlessness), Tardive Dyskinesia(involuntary movement of
tongue,lips,neck,trunk,limbs)
Antiemetic, Anticholinergic..all these due to blockade of D2 receptor..Prolactin elevation
with sec-generation, sexual dysfunction
T.E:
 treatment of Schizophrenia...prevention of drug-induced nausea...
Chlorpromazine used to treat hiccups........... Promethazine treat Pruritis...
Pimozide treat “Tourette disorder”.. Risperidone & Haloperidol treat “Tic disorder”
S.E:
Extra-pyramidal, Anticholinergic, Galactorrhea, Amenorrhea, infertility, Impotence
Cautions & Precautions= in seizure Patients, Agranulocytosis with Clozapine limit its use,

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