PHARMACEUTICS TEST PAPER FOR GAT PREPARATION AND PHARMACEUTICAL INTERVIEW

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Directions for questions 1-28: Each of the questions, statements, or

incomplete statements in this section can be correctly answered or

completed by one of the suggested answers or phrases. Choose the best

answer.

1. Which substance is classified as a weak electrolyte?

(A) glucose

(B) urea

(C) ephedrine

(D) sodium chloride

(E) sucrose

2. The pH value is calculated mathematically as the

(A) log of the hydroxyl ion (OH-) concentration.

(B) negative log of the OH-  concentration.

(C) log of the hydrogen ion (H+) concentration.

(D) negative log of the H+ concentration.

(E) ratio of H+/OH- concentration.

3. Which property is classified as colligative?

(A) solubility of a solute

(B) osmotic pressure

(C) hydrogen ion (H+) concentration

(D) dissociation of a solute

(E) miscibility of the liquids

4. The colligative properties of a solution are related to the

(A) pH of the solution.

(B) number of ions in the solution.

(C) total number of solute particles in the solution.

(D) number of unionized molecules in the solution.

(E) pKa of the solution.

5. The pH of a buffer system can be calculated with the

(A) Noyes-Whitney equation.

(B) Henderson-Hasselbalch equation.

(C) Michaelis-Menten equation.

(D) Young equation.

(E) Stokes equation.

6. Which mechanism is most often responsible for chemical degradation?

(A) racemization

(B) photolysis

(C) hydrolysis

(D) decarboxylation

(E) oxidation

7. Which equation is used to predict the stability of a drug product at room temperature from

experiments at accelerated temperatures?

(A) Stokes equation

(B) Young equation

(C) Arrhenius equation

(D) Michaelis-Menten equation

(E) Hixson-Crowell equation

8. Based on the relation between the degree of ionization and the solubility of a weak acid, the

drug aspirin (pKa 3.49) will be most soluble at

(A) pH 1.0

(B) pH 2.0

(C) pH 3.0

(D) pH 4.0

(E) pH 6.0

View Answer8. The answer is E[see].9. Which solution is used as an astringent?

(A) strong iodine solution USP

(B) aluminum acetate topical solution USP

(C) acetic acid NF

(D) aromatic ammonia spirit USP

(E) benzalkonium chloride solution NF

10. The particle size of the dispersed solid in a suspension is usually greater than

(A) 0.5 μm

(B) 0.4 μm

(C) 0.3 μm

(D) 0.2 μm

(E) 0.1 μm

11. In the extemporaneous preparation of a suspension, levigation is used to

(A) reduce the zeta potential.

(B) avoid bacterial growth.

(C) reduce particle size.

(D) enhance viscosity.

(E) reduce viscosity.

12. Which compound is a natural emulsifying agent?

(A) acacia

(B) lactose

(C) polysorbate 20

(D) polysorbate 80

(E) sorbitan monopalmitate

13. Vanishing cream is an ointment that may be classified as

(A) a water-soluble base.

(B) an oleaginous base.

(C) an absorption base.

(D) an emulsion base.

(E) an oleic base.

14. Rectal suppositories intended for adult use usually weigh approximately

(A) 1 g.

(B) 2 g.

(C) 3 g.

(D) 4 g.

(E) 5 g.

15. In the fusion method of making cocoa butter suppositories, which substance is most likely to

be used to lubricate the mold?

(A) mineral oil

(B) propylene glycol

(C) cetyl alcohol

(D) stearic acid

(E) magnesium silicate

16. A very fine powdered chemical is defined as one that

(A) completely passes through a #80 sieve.

(B) completely passes through a #120 sieve.

(C) completely passes through a #20 sieve.

(D) passes through a #60 sieve and not more than 40% through a #100 sieve.

(E) passes through a #40 sieve and not more than 60% through a #60 sieve.

17. Which technique is typically used to mill camphor?

(A) trituration

(B) levigation

(C) pulverization by intervention

(D) geometric dilution

(E) attrition

18. The dispensing pharmacist usually blends potent powders with a large amount of diluent by

(A) spatulation.

(B) sifting.

(C) trituration.

(D) geometric dilution.

(E) levigation.

19. Which type of paper best protects a divided hygroscopic powder?

(A) waxed paper

(B) glassine

(C) white bond

(D) blue bond

(E) vegetable parchment

20. Which capsule size has the smallest capacity?

(A) 5

(B) 4

(C) 1

(D) 0

(E) 000

21. The shells of soft gelatin capsules may be made elastic or plastic-like by the addition of

(A) sorbitol.

(B) povidone.

(C) polyethylene glycol (PEG).

(D) lactose.

(E) hydroxypropyl methylcellulose.

22. The United States Pharmacopeia (USP) content uniformity test for tablets is used to

ensure which quality?

(A) bioequivalency

(B) dissolution

(C) potency

(D) purity

(E) toxicity

23. All of the following statements about chemical degradation are true except

(A) as temperature increases, degradation decreases.

(B) most drugs degrade by a first-order process.

(C) chemical degradation may produce a toxic product.

(D) chemical degradation may result in a loss of active ingredients.

(E) chemical degradation may affect the therapeutic activity of a drug.

24. All of the following statements concerning zero-order degradation are true

except

(A) its rate is independent of the concentration.

(B) a plot of concentration versus time yields a straight line on

rectilinear paper.

(C) its half-life is a changing parameter.

(D) its concentration remains unchanged with respect to time.

(E) the slope of a plot of concentration versus time yields a rate constant.


25. All of the following statements about first-order degradation are true except

(A) its rate is dependent on the concentration.

(B) its half-life is a changing parameter.

(C) a plot of the logarithm of concentration versus time yields a straight line.

(D) its t 9 0 % is independent of the concentration.

(E) a plot of the logarithm of concentration versus time allows the rate constant to be determined.

26. A satisfactory suppository base must meet all of the following criteria except

(A) it should have a narrow melting range.

(B) it should be nonirritating and nonsensitizing.

(C) it should dissolve or disintegrate rapidly in the body cavity.

(D) it should melt < 30°C.

(E) it should be inert.

27. Cocoa butter (theobroma oil) exhibits all of the following properties except

(A) it melts at temperatures between 33°C and 35°C.

(B) it is a mixture of glycerides.

(C) it is a polymorph.

(D) it is useful in formulating rectal suppositories.

(E) it is soluble in water.

28.United States Pharmacopeia (USP) tests to ensure the quality of drug

products in tablet form include all of the following except

(A) disintegration.

(B) dissolution.

(C) hardness and friability.

(D) content uniformity.

(E) weight variation.


Directions for questions

29-30: The questions and incomplete statements in this section can be

correctly answered or completed by one or more of the suggested answers.

Choose the answer, A-E.

29. Forms of water that are suitable for use in parenteral preparations

include

I. purified water USP.

II. water for injection USP.

III. sterile water for injection USP.

A if I only is correct

B if III only is correct

C if I and II are correct

D if II and III are correct

E if I, II, and III are correct

30. The particles in an ideal

suspension should satisfy which of the following criteria?

I. Their size should be uniform.

II. They should be stationary or move randomly.

III. They should remain discrete.

A if I only is correct

B if III only is correct

C if I and II are correct

D if II and III are correct

E if I, II, and III are correct


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