TOXICOLOGY - Summarize List of issues Toxicology Mechanisms and Methods

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 TOXICOLOGY

Toxicity = Inherent capacity of chemical to cause injur...dose & duration dependent

Acute toxicity: conversion of Xenobiotics into Nucleophilic specie

Chronic toxicity: conversion of Xenobiotics into Electrophilic specie

Warfarin is Rodenticide...Malathion Θ AcetylCholinEsterase, Ach toxicity

Asbestos is Carcinogenic

CCL4: from consumption of Contaminated water...cause Irritation of Eyes & Respiratory

Chloroform:Hepaatotoxic, Nephrotoxic

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Benzene: Hematopoietic toxicity...Agranulocytosis, Leukopenia

Toluene: CNS impair Speech, hearing, vision

Methanol (Wood Alchol) & Ethylene Glycol: Methanol oxidizes into Formic acid...

Ethylene Glycol oxidized into Glycolic, Oxalic, and Glyxolic acid

Isopropnol: metabolize into Acetone, then COOH, cause Acedemia

Organophosphate & Carbmate= Inseecticides....ΘAcetylCholinesterase

Pyrethroids: Insecticide...↑Na+...Convulsion, itching...S.E; Contact Dermatitis, Asthma

Rotenone: Insectiside... ΘNAD+ by ↓O2

Lead: Child more susceptible...Cause Hypochromic Microcystic Anemia, Constipation,

lower IQ, Convulsion...

Mercury : Memory loss, ↓verbal skills, inflammation of Kidney...Paresthesia, Vision,

mental confusion

Cadmium : from Fertilizer & Menure, Cigerette smoke...Bind to Melatothionin

CO=bind to Hb....Hypoxia, Dyspnea, Lethargy, seizure

Cyanide : bind to Metalloenzyme....ΘCytochrome a3...ΘCellular respiration

Silica=cause Silicosis”Lung disease, Fibrosis, Emphysema

Asbestos: Lung cancer

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ANTI-DOTES

checkout the youtube channel 

DESIGNER & STREET DRUGS

MDMA=methyleneDioxyMethAmphetamine central stimulant...used in “RAVE” parties

γ-HydroxyButyric acid= GHB rapidly abuse activate GABA B

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