Anthelmintic Drugs Lipincott And kadzung Review for screening test and interview preparation

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 Drugs for Nematode 

#QuizTime #diabetes #pharmaphila #interactions #pharmacist #pharmacology #pharmacistlife #hospitalpharmacist #research


Mebendazole 

DOC in infections of Whipworm (Trichuris trichiura), Pinworm(Entrobius vermicularis), Hookworm (Necator americanus), Roundworm(Ascaris lumbricoides) 

MOA

bind to Parasite‟s microtubules…↓Glucose uptake.. Parasite expel with feces… Embryotoxic & Teratogenic

Pyrantal Pamoate

Depolarizing agent..Neuromuscular blocker...Paralyzed parasite 

Thiabendazole

👍used in Strongloidiasis & Trichinosis…interefer with microtubules… 

❌contraindicated in pregnancy 

Ivermectin

DOC in Onchocerciasis (river blindness) by O.vulvulus….↑CI- influx… 

Hyperpolarization, paralysis of Parasite…Contraindicated in Meningitis, Pregnancy

👉Killing of Microfilaria result in Mazotti-like reaction (fever, hypotension,headache) 

Diethylcarbamazepine

used in Filariasis….

S.E

anthralgia, Myalgia, Leukocytosis.

Drugs for Trematode 

Fluke leaf-shaped…affect liver, lung, intestinal, blood 

Praziquantal

DOC in Schistosomiasis & Cysticercosis…

 Ca++↑… ↑contraction,

Paralysis used in pregnancy,,,

S.E

Anorexia,malaise.

Drugs for Cestode 

True Tapeworm, Segmented,flat, attach to intestine 

Niclosamide

 DOC for cestode…ϴMitochondrial phosphorylation of ADP….ϴ of ATP.. 

Albendazole

ϴmicrotubule synthesis,↓Glucose uptake…used in Cysticercosis,Hydatid disease…

S.E

 hepatotoxicity, Agranulocytosis, Hyperthermia…Contra in pregnancy

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